221: Inflammation, Systemic Enzymes & SPMs with Carly Stagg, FNP
In this week’s podcast episode, Carly and I are talking all about:
✔️The inflammatory process
✔️Why you don’t want to stop the inflammation process too early (like with NSAIDs or acetaminophen)
✔️Why we NEED inflammation and compounds like cholesterol and SPMs as part of the process
✔️The difference between regular fish oil and exogenous SMPs
✔️How to use systemic enzymes to support the anti-inflammatory process.
Come listen for some great insight and our two favorite anti-inflammatory supplements!
EPISODE 221: Inflammation, Systemic Enzymes & SPMs with Carly Stagg, FNP
SHOW NOTES
(0:00) Intro
(1:02) Carly is back on the podcast to talk about 2 powerhouse supplements: systemic enzymes and Specialized pro-resolving mediators.
(4:12) Defining inflammation and breaking down acute versus chronic inflammation
(6:40) Breaking down the first stage of the inflammatory response (immune initiation)
(13:18) Explaining the second stage of the inflammatory response (immune resolution)
(19:10) The role of cholesterol in the inflammatory response
(21:00) Inflammation markers
An optimal hsCRP is less than 1.0. An hsCRP in moderate inflammation is between 1 and 3, while an hsCRP in severe inflammation is 3 or greater.
Elevated homocysteine can be related to poor methylation, which enables the usability of B vitamins, as well as generalized inflammation.
An optimal Homocysteine is less than about 6.
Total Cholesterol reflects the summary of all cholesterol types in blood; non-specific. Cholesterol tends to rise with age as the body addresses increased inflammation.
Optimal range varies by age and gender.
<60 yo : 150-230
>60 yo male: 180-260
>60 yo female: 200-270
(27:12) When to know if your body needs more support
High and rising CRP levels, continued chronic pain and fatigue, high homocysteine, high GGT.
(30:28) Lipid & Inflammation Healing Solutions
Consume enough fatty acids for optimal inflammatory response
Ensure nutrient sufficiency
Magnesium
Folate
B12
Systemic Enzymes
Systemic Enzymes
“Pac Man” for inflammation - it goes into the body/bloodstream and “chomps” up all the little inflammatory molecules and fibrin, which are byproducts of inflammation and impair cellular communication
Dissolve-It-All
Supports cardiovascular and chronic inflammatory health
Contains Serrapeptase & Nattokinase, as well as other complementary ingredients (Bromelain, Papain, Lipase, Proteases, Rutin & Amla)
Serrapeptase: Research shows serrapeptase possesses significant anti-inflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. It reduces scar tissue, improves tissue healing and supports a healthy respiratory system.
Nattokinase: Nattokinase has powerful anti-inflammatory and fibrin-degrading activity.
Suggested use is to take 1-3 capsules daily on empty stomach; if taken WITH food it will aid in protein digestion. Fine, but not the goal :)
Intenzyme Forte
Pain, headaches, chronic inflammation, also doubles as digestive enzyme when consumed with food
4-6 tablets daily on an empty stomach
SPM Active
Supercharged compound derived from fish oil to regulate/balance the immune response and reduce hyperactivity. The body should be able to MAKE SPMs from Omega-3 supplementation and/or things in our diet.
You’ll remember from earlier in our discussion that in phase 2 of inflammation, production of pro-resolving mediators (SPMs) presses the STOP button on inflammatory functions and symptoms and promotes waste removal & tissue regeneration. So giving exogenous SPMs is a great additional support!
Can take 2 capsules 2-3x daily for acute inflammation, then 2 capsules daily ongoing.
This is a great support for elevated CRP & homocysteine (unrelated or unresponsive to B vitamin supplementation)
(54:00) How should we approach taking systemic enzymes long-term?
(59:00) Anchor Questions
(1:02:00) Special message from Carly about The School of Christian Health & Nutrition
(1:03:15) Outro & Disclaimer
IMPORTANT DATES:
9.21-10.9: Regular Registration $4495
10.2: Class begins! Mondays @ 1:30 CST
Resources and Programs
Join the Sunday Sendout List
Join the The Christian Health Club
STUDIES
Therapeutic application in Alzheimer’s: Serrapeptase and nattokinase intervention for relieving Alzheimer's disease pathophysiology in rat model
Supplement access
Dissolve-It-All: use code TCN for discount
Metagenics SPMs:
Fullscript: https://us.fullscript.com/welcome/thechristiannutritionist (better price)
Chelsea’s Covid recs:
Dissolve-It-All: use code TCN for discount
Cellcore’s ViRadChem Binder
Cellcore’s BC ATP (mitochondrial support)
Patient direct code: cAydJR57
Thanks for listening! Have a healthy and blessed week!